COMT
Type: Concept
As of November 2026, COMT has been mentioned in 3 episodes across 2 podcasts, first heard Jan 2023 on Gary Brecka.
Catechol-O-methyltransferase is one of several enzymes that degrade catecholamines, catechol estrogens, and various drugs and substances having a catechol structure. In humans, catechol-O-methyltransferase protein is encoded by the COMT gene. Two isoforms of COMT are produced: the soluble short form (S-COMT) and the membrane bound long form (MB-COMT). As the regulation of catecholamines is impaired in a number of medical conditions, several pharmaceutical drugs target COMT to alter its activity
| Mentioned in | 3 episodes on 2 podcasts (as of November 2026) |
|---|---|
| First heard | Jan 2023 on Gary Brecka |
| Field | Genetics; neuroscience |
How do different shows talk about COMT?
2 shows discussed COMT in these episodes.
- Gary Brecka — 2 episodes
- PowerfulJRE — 1 episode
Who talks about COMT on podcasts?
Joe Rogan brought up COMT; the most recent mention was Jun 2024 on PowerfulJRE.
- Joe Rogan Experience #2060 - Gary Brecka on PowerfulJRE (Jun 2024) — Joe Rogan
- Path To Mastery x Gary Brecka on Gary Brecka (Jan 2023)
- Dropping Bombs with Brad Lea x Gary Brecka | Full Episode on Gary Brecka (Jan 2023)
What is COMT mentioned alongside?
COMT is most often mentioned alongside manic depression, Mother Nature and hypoxia.
Mentioned together: manic depression, Mother Nature, hypoxia, Neural tube defect, US government (federal government), Z, hydrogen cyanide, Flintstones vitamins, cyanocobalamin, hydroxycobalamin