ibogaine

Type: Concept

As of November 2026, ibogaine has been mentioned in one podcast episode on The Daily Show (Feb 2026). Central to the discussion as an experimental psychedelic treatment for veterans with PTSD and trauma.

Ibogaine is a psychoactive indole alkaloid derived from plants such as Tabernanthe iboga, characterized by hallucinogenic and oneirogenic effects. Ibogaine exhibits complex pharmacology by interacting with multiple neurotransmitter systems, notably affecting opioid, serotonin, sigma, NMDA, and nicotinic acetylcholine receptors; its metabolite noribogaine primarily acts as a serotonin reuptake inhibitor and κ-opioid receptor agonist.