Antimicrobial Resistance: a silent pandemic (BSL-interpreted)

What is discussed, and when

1. 0:00 – 3:00: Tori Kinnaman
2. 6:00 – 9:00: Felix Leao, World Health Organization

Notable quotes from "Antimicrobial Resistance: a silent pandemic (BSL-interpreted)"

• Hello, my name is Tori Kinnaman and I am an AMR survivor, patient advocate, and recently graduated medical student pursuing a residency in orthopedic surgery. My first confrontation with AMR.

  about Tori Kinnaman · at 0:13

• So, it's the reason why I was happy to join the WHO task force of AMR survivors to make sure that everyone understands the silent pandemic that antimicrobial resistance is that we're looking at the end of the antibiotic.

  about World Health Organization · at 6:38

• Currently I'm working as a pediatrician majoring in ICU in Harapankita National Women and Children Health Center, Jakarta. Talking about AMR may not be separated from my professional.

  about Felix Leao · at 8:10

Who and what is mentioned in this episode?

People

• Tori Kinnaman — Person · Main speaker · 2 mentions · first at 0:13
  Shares a personal AMR/MRSA survival story and connects it to her path as a patient advocate and future orthopedic surgeon, emphasizing prevention and infection control in athletics.
• Felix Leao — Person · Main speaker · 1 mention · first at 8:06
  Provides a clinician and caregiver perspective on AMR from ICU pediatrics and the loss of his son to sepsis involving multi-resistant organisms, advocating for proper diagnosis, vaccination, and hygiene.

Companies & orgs

• World Health Organization — Company · Referenced organization · 1 mention · first at 6:38
  Mentioned in the context of forming a task force for AMR survivors, highlighting its role in addressing antimicrobial resistance.

Full transcript with timestamps

0:13 Hello, my name is Tori Kinnaman and I am an AMR survivor, patient advocate, and recently graduated medical student pursuing a residency in orthopedic surgery. My first confrontation with AMR occurred when I was a freshman in college. I was doing division 1 collegiate gymnastics at the time and about a week after our major championship competition, I had the gradual onset of pain in my left hamstring. Over the course of a week and after a number of misdiagnoses, I was eventually admitted to the hospital for a suspected cellulitis or skin and soft tissue infection and started on broadspectctrum antibiotics. However, within 48 hours, my condition precipitously declined and I was taken in for emergency surgery. That's when the surgeons discovered that I had an 18cm abscess and associated muscle infection of my hamstring. It turned out to be a methasylan resistant staff orius infection. I had eight surgeries in 2

1:05 weeks. Spent over the month in the hospital including 5 days in the ICU and the next 5 months recovering at home. When I went back to school the following semester, I dedicated myself to research. I wanted to understand why infections happen to certain people and how we can prevent the spread of those infections. Uh so I really dove into infection prevention and control particularly in an athletic setting as multi-drugresistant infections are much easier to prevent than they are to treat. So I think that that is a key area that needs much improvement moving forward. I will always remember what it felt like to be a patient lying in a hospital bed, not knowing if I was going to have my leg amputated in the upcoming surgery or even if we were going to be able to treat the infection that was raging through my body. And that is something that I will always take with me as a doctor moving forward. Hi, my name is Bakti. I'm an

1:57 XDR tuberculosis survivor. In 2017, I was living perfectly healthy life and completing my final year project when I started observing weight loss, weakness and stomach issues. With few medication, I managed to complete my degree and started looking for a job. Soon I observed a lymphatic swelling on right side of my neck. I visited a doctor who had done some primary investigation and prescribed me with the first line TB medications. I went for a second opinion of an expert doctor who asked me to undergo a biopsy and few advanced testing. I was diagnosed with the extensive drugresistant tuberculosis in which only 30 to 50% people survive.

2:51 My 2 years treatment was that with the eight different antibiotics for 2 years and daily painful injections for 8 months. This treatment comes with a cure as well as severe side effects like anxiety depression nausea vomiting. My skin tone changed to reddish brown color. I also suffered from an optical neuropathy which results in a blurred vision. AMR is a silent pandemic. Drug resistance strains are already circulating in an environment. If it can happen to me, it can happen to anyone. Be aware of AMR. Good afternoon everyone. My name is Mashid from Nigeria. Let me clear my profession.

3:43 In August 2020 I developed kisto or diagas of kines. It was partially treated with trips the laser technology and effectually it had to be completed. The process had to be remove to be completed with open surgery. After the sa I was given antibiotics. I was discharged after about 10 days with a catheter. 3 weeks later the catheter was removed and three other months later I went back to the hospital to remove the state. I developed cold and temperature and I was shifting. I naturally thought it was man. I went for malaria treatment to act. I felt all right but surprisingly a few days later the symptoms suffixed and I decided to go for laboratory test in a local in my community. The outcome was tered and vania again. About 10 days later after I felt relief the symptoms came up and at that time I was diagonized of having contracted COVID 19. I had to be admitted was on oxygen for about 9 days at the hospital.

4:51 After about 17 days in the hospital, I was discharged both with the symptoms of the UT persistence and I had to go for another laboratory test which now shows that it was no longer in but staff or the experience was frightening. It was life-threatening. In fact, I almost died when it become combined with COVID 19. The observation there is that we need to improve on standards expend of the laboratories around. We also need to increase the training or capacity of the laboratory staff. We also need to ensure that we have standard antibiotics and by improving supply chain and quality of product. Thank you.

5:45 I want to live. I'm not ready to die. My mom pleaded with a consultant as she lay in hospital during COVID suffering from a drugresistant sudamonus infection deep in her lungs. She'd been hospitalized several times with infection. This time the second line antibiotic hadn't worked. The fact that I was allowed to visit her told me they didn't think she'd make the night because visits during COVID times were not allowed until end of life. But they found an antibiotic that worked. She did live. Thank you to those antibiotics. Due to recurrent infections, they've decided she should now be on long-term antibiotics, which for the last 2 years has kept her infectionfree. But we both know one day these antibiotics too will stop working.

6:38 So, it's the reason why I was happy to join the WHO task force of AMR survivors to make sure that everyone understands the silent pandemic that antimicrobial resistance is that we're looking at the end of the antibiotic

6:59 age. As an infectious diseases clinical pharmacist leading antimicrobial stewardship programs, it was really difficult for me to experience AMR through my mother's post-operative urinary tract infection. Finding the needed antibiotics was challenging and even when available, my mother couldn't understand why we have such inefficient treatment options for such a common illness. So in addition to the pain, frustration and financial burden of her recurring infection, the stigma and psychological impact during the already tough Lebanese economic crisis was significant on her and on my family as a whole. My perception of AMR changed from purely medical to a sociobehavioral economic problem where anything from the direct home environment to access to medicines and neighborhood parks to war and climate change impact the risk for AMR as well as its outcomes.

7:46 I realized that AMR really is a symptom of failed health systems and in order to tackle AMR, significant cross- sectoral collaboration and research on both medical aspects and behavioral change leading to healthier environments is needed by policy makers, educators, healthcare workers and patients. My name is Felix Leao from Indonesia. Currently I'm working as a pediatrician majoring in ICU in Harapankita National Women and Children Health Center, Jakarta. Talking about AMR may not be separated from my professional experience as a doctor and my personal experience as a caregiver. Most of my patients suffer from severe phenotype of disease.

8:37 They need multi-invasive treatments and they also need high level of antibiotics due to AMR. Most of them died. Another point of view is my personal experience as a doctor. It was 2019 when my first son was born. He kept vomiting. He kept diarrhea since early in life. He could not tolerate to any kind of milk from breast milk to medical purpose formula milk. He was prescribed many kinds of antibiotics without improvement. Earlier blood culture showed negative results but next blood culture showed multi-resistant of gram positive. He didn't come to home with parental nutritions.

9:32 In the end, I lost him. I lost my son due to sepsis. AMR is real. AMR is invisible. But for me, it's not. From the story above, we can learn some points. First, proper diagnosis should be made before prescribing antibiotics. Second, beware of hospitalacquired infection. do not go to the hospital or do not need hospital admission if there is no indications if there is no emergency. Her vaccine and a good hygiene habit can prevent AMR. So please keep your children vaccine up to date. Thank you.

Questions about this episode

What is discussed in "Antimicrobial Resistance: a silent pandemic (BSL-interpreted)"?

In order: 0:00 Tori Kinnaman; 6:00 Felix Leao, World Health Organization.

What is mentioned in this The Lancet episode?

3 people, works and ideas are mentioned, including Tori Kinnaman, Felix Leao, World Health Organization. Each one on this page links to its own page with every episode that mentions it.

How long is "Antimicrobial Resistance: a silent pandemic (BSL-interpreted)"?

The episode runs 11 min; the transcript is about 1,406 words in 12 timestamped sections.

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